Nootropic supplements have been on the rise since the Limitless movie and TV series introduced the world to the fictional pill called NZT-48.
BrainPill is one of the latest smart pills. Does it work? Is it worth it?
If you haven't got much time, we've put a TL;DR box first to give you the highlights. Otherwise the full review is below, with full scientific study references at the end.
- It's an effective product
- It's packed with scientifically proven ingredients – more so than anything else we've tested
- It comes with a money back guarantee
- It's safe
- No it won't turn you into Bradley Cooper on NZT-48 in Limitless because he's an actor, it doesn't exist, and movies aren't real life.
- YES, it's worth it!
BrainPill is a nootropic supplement designed to improve cognitive function and memory and improve productivity.
Looking at the ingredients, there are some neuro-protective agents included as well. This is a criterion that is all too often missing from modern nootropic products, even though it is one of those which originally defined what they were.
BrainPill is manufactured by the same company that makes VigRX Plus and GenF20: Leading Edge Health.
As a sign of confidence in their product, Leading Edge have even put a memory test on the website that you can take before you start using BrainPill, and then repeat as desired over time in order to see improvement.
What are the Benefits of BrainPill?
BrainPill’s tagline is “…your unfair advantage.”
The company promises improvements in four major areas of cognitive function:
Looking at these benefits in more detail, the specific actions of the ingredients should have the following effects:
- Faster Information Processing
- Enhanced Productivity / Efficiency
- Improved Learning Speed and Capacity
- Quicker Memory Recall
- Improved Multi-Tasking
- Heightened Focus and Concentration
- Faster Reaction Time
- Augmented Brain Metabolism
- Reduced Oxidative Stress
The important question is whether BrainPill can actually trigger this extensive list of benefits in the user, and whether it's to an extent that is worth spending money on.
As usual, a closer look at the ingredients will give us a better idea.
BrainPill contains more ingredients than we are used to seeing in a nootropic product.
In the Scientific Study Sources – References (below this review) section there are numerous scientific studies listed with links to the full reports. These will corroborate in more detail the potential benefits of the following ingredients.
We will provide a brief summary of each ingredient’s effect
Cognizin – Citicoline
Improved memory, focus, concentration, accuracy, energy, attention, speed of cognition.
A precursor to very important neurotransmitters such as acetylcholine, Citicoline improves memory and cognition.
Cognizin is the patented and most powerful form of Citicoline on the market. It boosts mental energy and helps prevent cognitive decline as the brain ages.
Reaction time and focus were also shown to be increased following supplementation of this compound.
Synapsa – Bacopa Monnieri
Faster Information Processing, learning, memory retention, better multi-tasking
Bacopa Monnieri is a herb which scientific studies have repeatedly supported for its cognition and memory enhancing properties.
The bacosides contained within it appear to be the active agent; repairing neurons to improve signal transmission across nerve endings.
Bacopa is also making a name for itself as a potential treatment for Alzheimer’s and age-related cognitive decline.
Prevents the breakdown of the principal neurotransmitter acetylcholine by the enzyme acetylcholinesterase. This increases the amount of acetylcholine.
Acetylcholine is known for its ability to help people learn, and also for more powerful muscle contractions. Huperzine A is showing promise for being a treatment for Alzheimer’s disease.
Known as a cerebral vasodilator; widening the blood vessels of the brain in order to provide it with more blood, and therefore more valuable oxygen. Vinpocetine may also boost memory.
Reliably improves short term memory and reduces cognitive decline as the body and brain ages.
Also known as Cobalamin, Vitamin B12 plays important roles in neurology. An easy way to maintain long term brain health – and size – but it is nevertheless overlooked by many people.
Working together with DHA and other B vitamins (B12 and B9), Vitamin B6 increases levels of acetylcholine and thus improves mental performance. Another vitamin that people can fall short on in diet.
DHA – Docosahexaenoic Acid
A type of fish oil which plays an important role in cognitive health. Synergistic with Phosphatidylserine, which is also in the BrainPill blend. Both of these compounds help each other to work more effectively.
PS is found in the brain in high amounts. Studies show that it improves short term memory, specifically pertaining to numbers, names, facts and important daily information.
A precursor to major neurotransmitters noradrenaline (norepinephrine) and dopamine. It helps memory retention and clear thinking during stressful periods and acts as a general anti-stress agent.
Promotes alpha-waves in the brain that induces relaxation without sedation. Generally accepted as an anti-stressor and helps maintain thought processes while under stress.
Pantothenic Acid (Vitamin B5)
Essential to survival but not manufactured by the body, we must source this Vitamin from diet, and now supplements. B5 is heavily involved in the production and maintenance of Acetylcholine levels.
Folic Acid (Vitamin B9)
A fundamental Vitamin during the initial stages of our brain and spine formation in the womb, it becomes more important for emotional strength in adulthood. It’s anti-depressive effects are well documented.
Becoming a must inclusion in most capsule supplements these days as it improves the entire supplement’s absorption and bioavailability.
Who Should Use BrainPill?
The extensive formula in BrainPill means that there is no specific target user group.
BrainPill is suited to anyone, including students who are knee deep in coursework and exams, to people who are starting to forget things more often than they care to admit.
Are There any Side Effects?
Provided the recommended dosage is followed from the product packaging, there should be no side effects experienced for the average person.
Anyone unsure as to whether BrainPill is suitable for them can simply check with their doctor.
The ingredients used by Leading Edge Health have always been of the highest quality in our experience.
Conclusion and Recommendations
Manufactured by a well known and trusted manufacturer, and with a host of research-backed ingredients, BrainPill gets our vote.
It is perhaps the most comprehensive nootropic supplement available today.
Purchasing and Guarantee
BrainPill can be purchased from the product website in packages of 1 to 12 bottles. Maximum value will be gained from the 12 bottle package, but there are options in the middle that are more popular.
The company offers a full refund to people who don’t get the experience they are expecting.
BrainPill can be shipped all over the world, including to the US, UK, Ireland, Europe, Australia, Canada and more.
Scientific Study Sources – References
Cognizin – Citicoline
McGlade et al. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. 2012. [http://www.scirp.org/journal/PaperInformation.aspx?paperID=19921]
Alvarez XA et al. Citicoline improves memory performance in elderly subjects. 1997. [http://www.ncbi.nlm.nih.gov/pubmed/9203170]
Spiers PA et al. Citicoline improves verbal memory in aging. 1996. [http://www.ncbi.nlm.nih.gov/pubmed/8624220]
Mario Fioravanti and Ann E Buckley. Citicoline (Cognizin) in the treatment of cognitive impairment. 2006. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695184/]
Pietro Gareri et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. 2015. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562749/]
Synapsa – Bacopa Monnieri
Stough C et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. 2001. [http://www.ncbi.nlm.nih.gov/pubmed/11498727]
Raghav S et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. 2006. [http://www.ncbi.nlm.nih.gov/pubmed/20703343]
Stough et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. 2008. [http://www.ncbi.nlm.nih.gov/pubmed/18683852]
Roodenrys S et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory. 2002. [http://www.ncbi.nlm.nih.gov/pubmed/12093601]
Calabrese C et al. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. 2008. [http://www.ncbi.nlm.nih.gov/pubmed/18611150]
Morgan A et al. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20590480]
Sebastian Aguiar. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. 2013. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/]
Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. 2006. [http://www.ncbi.nlm.nih.gov/pubmed/17056129]
Hai-yan Zhang. New insights into huperzine A for the treatment of Alzheimer's disease. 2012. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003111/]
Subhan Z, Hindmarch I. Psychopharmacological effects of vinpocetine in normal healthy volunteers. 1985. [http://www.ncbi.nlm.nih.gov/pubmed/3899677]
AO Ogunrin. Effect of Vinpocetine (Cognitol™) on Cognitive Performances of a Nigerian Population. 014. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160700/]
Chukanova EI. Efficacy of cavinton in the treatment of patients with chronic blood flow insufficiency. Russian multicenter clinical-epidemiological program “CALIPSO”. 2010. [http://www.ncbi.nlm.nih.gov/pubmed/21311488]
Vorob'eva OV, Tamarova ES. Efficacy of vinpotropile in the therapy of initial signs of cerebrovascular pathology. 2010. [http://www.ncbi.nlm.nih.gov/pubmed/21183904]
Santos RF et al. Cognitive performance, SPECT, and blood viscosity in elderly non-demented people using Ginkgo biloba. 2003. [http://www.ncbi.nlm.nih.gov/pubmed/12905098]
Yancheva S et al. Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial. 2009 [http://www.ncbi.nlm.nih.gov/pubmed/19347685]
Kanowski S et al. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. 1996 [http://www.ncbi.nlm.nih.gov/pubmed/8741021]
Scholey AB, Kennedy DO. Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand. 2002 [http://www.ncbi.nlm.nih.gov/pubmed/12404705]
Brautigam MR et al. Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double blind placebo-controlled study. 1998. [http://www.ncbi.nlm.nih.gov/pubmed/23196025]
Mix JA, Crews WD Jr. An examination of the efficacy of Ginkgo biloba extract EGb761 on the neuropsychologic functioning of cognitively intact older adults. 2000 [http://www.ncbi.nlm.nih.gov/pubmed/10890330]
Kaschel R. Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. 2011. [http://www.ncbi.nlm.nih.gov/pubmed/21802920]
Mix JA, Crews WD Jr. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. 2002. [http://www.ncbi.nlm.nih.gov/pubmed/12404671]
Kennedy DO. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. 2002. [http://www.ncbi.nlm.nih.gov/pubmed/12020739]
Zhang SJ, Xue ZY. Effect of Western medicine therapy assisted by Ginkgo biloba tablet on vascular cognitive impairment of none dementia. 2012. [http://www.ncbi.nlm.nih.gov/pubmed/22840457]
Attia A et al. Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood. 2012. [http://www.ncbi.nlm.nih.gov/pubmed/22700031]
Bäurle P et al. Safety and effectiveness of a traditional ginkgo fresh plant extract – results from a clinical trial. 2009. [http://www.ncbi.nlm.nih.gov/pubmed/19657199]
Masayuki Hashiguchi et al. Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia. 2015. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729005/]
Stefan Weinmann et al. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. 2010. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846949/]
Mashayekh A et al. Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study. 2011 [http://www.ncbi.nlm.nih.gov/pubmed/21061003]
Wesnes K et al. A double-blind placebo-controlled trial of tanakan in the treatment of idiopathic cognitive impairment in the elderly. 2004. [http://onlinelibrary.wiley.com/doi/10.1002/hup.470020305/abstract]
Woelk H et al. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. 2006 [http://www.ncbi.nlm.nih.gov/pubmed/16808927]
Jezova D et al. Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers. 2002. [http://www.ncbi.nlm.nih.gov/pubmed/12369732]
Narendran R et al. Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation. 2012. [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046832]
Yurko-Mauro K et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20434961]
Fontani G et al. Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. 2005. [http://www.ncbi.nlm.nih.gov/pubmed/16269019]
Jackson PA et al. DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. 2012. [http://www.ncbi.nlm.nih.gov/pubmed/22018509]
Parker AG et al. The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise. 2011. [http://www.ncbi.nlm.nih.gov/pubmed/22017963]
Vakhapova V et al. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20523044]
Crook T et al. Effects of phosphatidylserine in Alzheimer's disease. 1992. [http://www.ncbi.nlm.nih.gov/pubmed/1609044]
Engel RR et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. 1992. [http://www.ncbi.nlm.nih.gov/pubmed/1633433]
Klinkhammer P et al. Effect of Phosphatidylserine on Cerebral Glucose Metabolism in Alzheimer's Disease. 1990. [http://www.karger.com/Article/Abstract/107142]
Kato-Kataoka A et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. 2010. [http://www.ncbi.nlm.nih.gov/pubmed/21103034]
Hirayama S. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. 2014. [http://www.ncbi.nlm.nih.gov/pubmed/23495677]
Baumeister J. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. 2008. [http://www.ncbi.nlm.nih.gov/pubmed/18616866]
Kingsley MI et al. Effects of phosphatidylserine on exercise capacity during cycling in active males. 2006. [http://www.ncbi.nlm.nih.gov/pubmed/16394955]
Schreiber S et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. 2000. [http://www.ncbi.nlm.nih.gov/pubmed/11201936]
Neri DF et al. The effects of tyrosine on cognitive performance during extended wakefulness. 1995. [http://www.ncbi.nlm.nih.gov/pubmed/7794222]
Deijen JB et al. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. 1999. [http://www.ncbi.nlm.nih.gov/pubmed/10230711]
Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. 1989. [http://www.ncbi.nlm.nih.gov/pubmed/2736402]
Shurtleff et al. Tyrosine reverses a cold-induced working memory deficit in humans. 1994. [http://www.ncbi.nlm.nih.gov/pubmed/8029265]
Kimura K et al. L-Theanine reduces psychological and physiological stress responses. 2007. [http://www.ncbi.nlm.nih.gov/pubmed/16930802]
Ritsner MS et al. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. 2011. [http://www.ncbi.nlm.nih.gov/pubmed/21208586]
Song CH et al. Effects of Theanine on the Release of Brain Alpha Wave in Adult Males. 2003 [http://www.koreamed.org/SearchBasic.php?RID=0124KJN/2003.36.9.918&DT=1]
Higashiyama A et al. Effects of l-theanine on attention and reaction time response. 2011. [http://www.sciencedirect.com/science/article/pii/S1756464611000351]
Lu, Kristy, Gray, Marcus A., Oliver, Chris, Liley, David T., Harrison, Ben J., Bartholomeusz, Cali F., Phan, K. Luan and Nathan, Pradeep J. (2004) The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. 2004. [http://espace.library.uq.edu.au/view/UQ:284103]